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In canon (TV and movies) we know very little. The only film during the War is Insurrection, and it shows the Enterprise on a diplomatic mission, such with the Evora and resolving a dispute in the Goren system. Picard alludes to the Enterprise not being involved with much combat, and instead taking on diplomatic roles.

However, in non-canon (books, comics, games, et cetera) the Big E is involved in much of the war, spending considerable time on the front lines, and also playing a major role in the Liberation of Betazed (which was occupied halfway through DS9 season 6).

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