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Here are the fates of all the ships named Enterprise (not counting alternate timelines)

NX-01: Decommissioned

NCC-1701: Auto-destructed above the "Genesis Planet" (Star Trek III: The Search For Spock)

NCC-1701-A: Decommissioned

NCC-1701-B: Fate unknown (presumed destroyed)

NCC-1701-C: Destroyed fighting the Romulans (Star Trek: The Next Generation, "Yesterday's Enterprise")

NCC-1701-D: Destroyed in the battle of Veridian III (Star Trek: Generations)

NCC-1701-E: Active as of 2379

If we're talking about techincal destruction, as in being destroyed in action as opposed to merely being decommissioned, then the answer is three: the NCC-1701, the NCC-1701-C, and the NCC-1701-D.

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