Not exactly a well phrased question, but (to date) there hasn't been any USS Defiant's with that name in canon and non-canon. All we have is:-
- USS Defiant (NCC-1764), Constitution-class starship from TOS: "The Tholian Web" and ENT: "In a Mirror, Darkly"
- USS Defiant (NX-74205), Defiant-class prototype from Star Trek: Deep Space Nine
- A second USS Defiant (NX-74205), originally named USS Sao Paulo from DS9: "The Dogs of War" and "What You Leave Behind".